Research findings

Microglial (green) oxidative stress (red) following spreading depression in hippocampal slice culture
Microglial (green) oxidative stress (red) following spreading depression in hippocampal slice culture
  • Microglial (green) oxidative stress (red) following spreading depression in hippocampal slice culture
  • Microglia move long distances in a Lévy flight pattern in hippocampal slice culture.
  • Hypothermia stimulates increased expression of the anti-inflammatory cytokine interleukin-11, which reduces tumor necrosis factor-alpha-dependent neuroprotection from cold-preconditioning.
  • CD6 positive T cells were detected in the parenchyma of hippocampal slice cultures.
  • Dendritic cell cultures stimulated with IFNγ release exosomes that contain miRNA species that increase baseline myelination, reduce oxidative stress, and improve remyelination.