Cerebrovascular Disease and Aging Laboratories

Research Findings

Microglial (green) oxidative stress (red) following spreading depression in hippocampal slice culture

Microglia move long distances in a Lévy flight pattern in hippocampal slice culture.

Hypothermia stimulates increased expression of the anti-inflammatory cytokine interleukin-11, which reduces tumor necrosis factor-alpha-dependent neuroprotection from cold-preconditioning.

CD6 positive T cells were detected in the parenchyma of hippocampal slice cultures.

Dendritic cell cultures stimulated with IFNγ release exosomes that contain miRNA species that increase baseline myelination, reduce oxidative stress, and improve remyelination.